After falling about 7% and hitting one-year low of Rs 558.10 during the day, shares of the drug firm finally ended at Rs 587.95, down 1.81% on the BSE.
The market capitalisation of the company fell by Rs 34 crore to Rs 1,879 crore.
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Novartis had approached the apex court in 2009 against the order of Chennai-based Intellectual Property Appellate Board (IPAB), which had rejected its claim for patent. The MNC had applied for patent in 2006.
Novartis said: "This ruling is a setback for patients that will hinder medical progress for diseases without effective treatment options".
Among other drug companies, shares of Natco Pharma ended 5.44% higher, while Cipla rose by 1.20%.
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