The 30-share Sensex was down by 13.93 points to close at 3,447.45. The NSE S&P CNX Nifty lost 3.85 points to 1,085.35.
Profit taking continues to plague the markets after seeing over 13 per cent gains over the last four weeks. Both old and new economy counters saw a fall in their prices.
Infosys was among the only pivotal technology stock that managed to negate the trend.
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The weak close in the US markets also seemed to have affected sentiments in the sector, according to market sources.
Auto shares, especially two-wheeler players Bajaj Auto, TVS Motor and Hero Honda, ended with gains on expectations of a normal monsoon.
Cement scrips Grasim, Gujarat Ambuja and L&T ended lower on profit taking.
Pharma stocks were also big losers with Cipla and Dr Reedy