Adverse events during initial years of life may affect future mental health: Study

Latest findings suggest that the first three years of life may be an especially important period for shaping biological processes that ultimately give rise to mental health conditions.

The study claims that the timing of adverse experiences, including poverty, family and financial instability, and abuse, has more powerful effects than the number of such experiences or whether they took place recently.

According to the researchers, one of the major unanswered questions in child psychiatry has been 'How do the stressors children experience in the world make them more vulnerable to mental health problems in the future?'

"These findings suggest that the first three years of life may be an especially important period for shaping biological processes that ultimately give rise to mental health conditions. If these results are replicated, they imply that prioritizing policies and interventions to children who experienced adversity during those years may help reduce the long-term risk for problems like depression," said Erin Dunn, lead author of the study published in the Journal of Biological Psychiatry.

Studies conducted in both animals and humans have found that adverse experiences early in life can have lasting effects on epigenetics, the process by which chemical tags added to a DNA sequence control whether or not a gene is expressed.

These studies reported differences in DNA methylation, which can either silence or enhance gene expression, between individuals who were and were not exposed to early-life stressors.

The current study was designed to test the hypothesis that there are sensitive periods during which adversity is associated with even greater changes in DNA methylation. The investigators also compared that model to an accumulation hypothesis, in which the effects of adversity increase with the number of events, and a recency hypothesis, that the effects of adversity are stronger when events happened more recently.

As part of the study, the researchers analyzed data from a subgroup of more than 1,000 randomly selected mother/child pairs from which DNA methylation profiles had been run for the children at birth and at age 7.

The children's exposure to adversity before the age of 7 was based on whether parents reported their child's repeated experience of seven stressors:

* Abuse by a parent or other caregiver,* Abuse by anyone,* Mother's mental illness,* Living in a single-adult household,* Family instability,* Family financial stress,* Neighborhood disadvantage or poverty.

The investigators recorded the number of exposures to each adversity, whether or not they were experienced at specific developmental stages and how close they occurred to the age at which blood samples were taken for the second methylation profile.

The analysis identified 38 DNA methylation sites at which adverse experiences were associated with changes in methylation, most of which were associated with when the stressful experience had taken place. Adversity before the age of 3 had a significantly greater impact on methylation than did adversity at ages 3 to 5 or 5 to 7.

Exposure to adversity was typically associated with increased methylation, which would reduce the expression of specific genes; and neighborhood disadvantage appeared to have the greatest impact, followed by family financial stress, sexual or physical abuse, and single-adult households.

Although early-childhood experiences had the greatest effects, adversity at older ages was not without an impact. And while the results provide the strongest evidence for the sensitive or "vulnerable" period model, they do not totally rule out any effect related to the accumulation or recency hypotheses.

In fact, two of the sites at which methylation appeared to be changed by adversity were associated with either the number of adverse experiences or how recent they had been.

Researchers suggest that these additive effects may work together with the timing of exposure, so it would be interesting to examine more complex mechanisms in future studies with larger groups of participants.