Many iNPH patients can also develop Alzheimer's disease

One in five patients who suffered idiopathic normal pressure hydrocephalus (iNPH) remains at higher risk of developing Alzheimer's disease, says a new study.

The researchers were able to predict the development of Alzheimer's disease by using the Disease State Index (DSI) that combines patient-specific data from various sources.

The results were published in the 'Journal of Alzheimer's Disease'.

In iNPH, the circulation of cerebrospinal fluid (CSF) is disturbed for an unknown reason, leading to a slightly elevated brain pressure and dilation of the brain ventricles.

Symptoms of NPH include gait deviations, impaired short-term memory and urinary incontinence. Patients with iNPH often have changes in the brain that are related to Alzheimer's disease.

The study followed patients with iNPH after they had received treatment for their disease.

They were treated with shunt surgery in which excessive CSF is led from the brain ventricles to the abdominal cavity by using a CSF shunt.

Shunted NPH patients who had undergone brain tissue biopsy in connection with their surgery were selected for the study. The objective of the biopsy was to detect changes that are indicative of Alzheimer's disease.

During the follow-up, the researchers found that up to one in five patients with NPH were later diagnosed with Alzheimer's disease.

At the end of the follow-up, patients with NPH were more frequently diagnosed with Alzheimer's disease than the general population.

The researchers were able to predict the development of Alzheimer's disease, with moderate accuracy, by using patient-specific DSI.

The data used in DSI included the patient's pre-surgery symptom profile, brain tissue samples, and brain MRI images.