Many Republicans have joined Barack Obama in condemning presumptive Republic presidential nominee Donald Trump over his anti-Muslim stance and remarks alleging the US President to be a sympathiser of ISIS.
Following the mass shooting at an Orlando gay nightclub that killed 49 people, Trump called for a ban on immigration of Muslims to the country and also sought Obama's resignation on Monday.
Speaker Paul D Ryan of the Republican Party denounced Trump, saying the ban on Muslims is not in the country's interest.
"I do not think it is reflective of our principles, not just as a party but as a country," Washington Post quoted Ryan as saying.
Senate Foreign Relations Committee Chairman Bob Corker, who had earlier praised Trump, also expressed his disappointment at the latter's response to the tragedy.
"Traditionally, it is a time when people rally around our country, and it's obviously not what's occurred, and it's very disappointing," Corker said.
Obama on Tuesday warned the Republican leaders of Trump's "dangerous mindset" and "loose talk" and asked them to distance themselves from his remarks.
He also dismissed Trump's repeated demands for him to use the term "radical Islam" when speaking about the Orlando shootings and other attacks.
Disapproving Trump's remark, Obama said, "Calling a threat by a different name does not make it go away. This is a political distraction."
"This was a country founded on religious freedom. We don't have religious tests here," the Guardian quoted Obama as saying.
Extending her support to Obama, Hillary Clinton described Trump's response as rife with "conspiracy theories" and "pathological self-congratulations."
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