One worker, who jumped from the roof of the burning building, was killed and two others injured, Hong Kong-based South China Morning Post reported.
Many others remained trapped inside the building.
Screams for help could be heard as workers at the factory building ran to the roof in an effort to escape but got trapped by dense smoke.
Several explosions were heard, it quoted local media reports as saying.
The factory was located in Zhengzhou National Hi-Tech Industrial Development Zone.
A rescue operation is underway.
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