The bomb went off tonight near the MQM office at Burns Road, a neighbourhood in Karachi known for its eateries.
The blast also hit a mosque and nearby shops.
Police officials said the bomb was packed with ball bearings and triggered by remote control.
The wounded were taken to a nearby hospital.
Officials said one of the injured was in a serious condition.
Security forces cordoned off the area after the blast, which caused panic among local residents.
The banned Tehrik-e-Taliban Pakistan claimed responsibility for the attack.
Taliban spokesman Ihsanullah Ihsan called media outlets and said his group had carried out the attack on the MQM.
The Pakistani Taliban have vowed to target secular parties like the Pakistan People's Party, Awami National Party and MQM ahead of the polls.
The group has claimed responsibility for a string of bombings in Karachi that killed nearly 20 people, including ANP and MQM workers.
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