The minivan carrying women and children was hit by a truck on Lyari highway here and it plunged into the Lyari river breaching the safety barrier, police said.
"Those killed include five women and five children of one family," Aftab Channar, an official at the Civil hospital said.
Channar said six dead bodies were brought to the hospital but later out of the injured four succumbed to their injuries.
Channar said five people were being treated for injuries.
Rescue workers and police reached the accident spot to retrieve the minivan from the Lyari river.
The occupants of the minivan were relatives and were going to Lea market from where they had to travel to Quetta.
Police was currently on the look out for the truck driver, officials said.
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