Opener Quinton de Kock, who hit 108 in his side's eight- wicket loss, was rushed to a city hospital after the game, while three others were also hospitalised during the course of the match.
Cricket South Africa also issued a press release, saying that currently 10 of their players are in hospital.
"With half of the squad going down ill overnight South Africa was forced to play (against India A today) an ill- balanced starting XI that had only four frontline bowlers with the likes of Dean Elgar and Khaya Zondo to make up the rest of the overs," the CSA said.
In fact, de Kock had to be rushed into action less than 24 hours after arriving in India as six of his teammates were also on the sick bed.
Due to the hospitalisation of the players, India A will replace South Africa A in tomorrow's tri-series match against Australia A.
It has been learnt from sources that South Africa 'A' team management requested India A coach Rahul Dravid for a change in schedule as at least six of their players are not fit to take the field against Australia A tomorrow.
Dravid accepted their request and thus India A, instead of playing on Tuesday, will now play tomorrow against the Aussies.
The plight of the South African side was understandable when India A team's 12th man Mandeep Singh came in to field after de Kock suffered a hamstring pull.
