Local police said that no casualty has been reported in the incident.
A railway spokesperson said that the injured have been moved to nearby hospitals while senior officials have rushed to the site of the derailment at Natrampalli, about 140km from Bangalore.
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According to sources, the derailment occurred due to suspected rail fracture but the railway spokesperson said that the cause behind the incident is yet to be ascertained.
Meanwhile, the Railways have announced complete or partial cancellation of about 15 services, including the Chennai- Bangalore double decker express.
Railways have also operationalised helpline numbers following the incident, the spokesperson said, adding that further details are awaited.
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