The ill-fated bus met with the accident at Chidapani village of Palpa district along the Siddhartha Highway last night, police said.
Twelve people died on the spot while three others succumbed to injuries at Lumbini Medical College Hospital, police added.
The bus driver was also killed in the accident and the vehicle was completely damaged.
Four injured were said to be critical.
The accident occurred due to drunk driving, police said.
Both the bridegroom and bride were also injured but are safe.
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