The incident took place near Theri bypass in Khairpur area of Sindh province and police said that early morning thick fog and careless driving were the main reason for it.
"Seventeen people were killed and five others injured in the accident," according to local police.
Police and rescue officials said the death toll could rise as the some injured were in precarious condition.
The heavily loaded truck with coal lost control while overtaking and fell on the van, which was on its way to Sukkur from Ranipur in Sindh, police said.
Road accidents are common in Pakistan. Most of them are caused by careless driving, bad roads and faulty vehicles.
At least 59 people were killed while 18 others were injured when a passenger bus collided head-on with a truck on the same Theri bypass in 2014.
Earlier this month, a speeding bus carrying over 100 passengers fell into a ravine killing at least 27 people and injuring 69 others in Pakistan's Punjab province.
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