Police said 35 people were rushed to a hospital in the Tando Mohammad Khan district late last night, where 24 of them died. Six were women.
"They were celebrating the festival of Holi this week and purchased the cheap liquor from a dealer in Tando Muhammad Khan," senior police official in Hyderabad, Haq Nawaz, said.
"The condition of the remaining persons was also not good," he said.
Following the tragedy, residents staged a protest against the police for failing to stop the illegal sale of hooch in their neighbourhood.
The latest incident is a reminder of a similar tragedy in Hyderabad and Karachi in 2014 during Eid-ul Azha celebrations when 29 people had died after consuming hooch.
Alcohol consumption is banned in Pakistan for Muslims but non-Muslims are allowed to ration alcohol from special liquor shops run by provincial excise departments.
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