The attack took place yesterday when 10 buses carrying the Shia pilgrims stopped at a hotel in Taftan near the Iranian border.
Six of the attackers were killed by security forces after heavy exchange of fire, Home Minister Mir Sarfaraz Bugti, told reporters.
"As soon as the pilgrims came out of the buses to go to the hotel first a group of militants first opened indiscriminate fire on them and also threw hand grenades before rushing into the hotel and taking refuge there," Bugti said.
Authorities said there were 10 women among the dead.
Sunni-militant group Jaish-ul-Islam has claimed responsibility for the deadly attack.
A purported spokesman for the group, Azam Tariq, called Quetta-based journalists from an undisclosed location to claim credit for the deadly attack.
The home secretary of the province, Akbar Durrani confirmed to PTI that security forces were able to overpower the attackers after a few hours of heavy exchange of gunfire as the masked militants had come heavily armed and prepared for a siege.
"There were explosions after the buses were parked outside the hotels where the pilgrims were going to stay overnight before they commenced their journey back the following day," Durrani said.
Attacks on Shia pilgrims have increased in recent years in the Baluchistan province where in the past also such attacks have killed dozens and injured scores of pilgrims.
Two devastating bombings in Quetta killed nearly 200 Shias last year and were claimed by banned Sunni extremist group Lashkar-e-Jhangvi (LeJ) which has links to al-Qaeda.
Leading Shia organisations have announced they would hold countrywide protests and sit-ins against the attack.
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