The three inmates were always under authorities control, but went unaccounted for in the confusion as hundreds of inmates were bused to hospitals and others were taken to nearby jails because the crippled building had to be evacuated, Escambia County spokeswoman Kathleen Castro said. One inmate described the blast.
"The explosion shook us so hard it was like we were in an earthquake," Monique Barnes, an inmate who said she was knocked off her fourth-floor bunk, told The Associated Press by phone. "It was like a movie, a horrible, horrible movie."
Barnes, who spoke to AP after she was taken to another jail, said she and other inmates complained of smelling gas ahead of the blast, and some reported headaches.
Escambia County Sheriff David Morgan wouldn't comment on whether inmates complained about gas. He said three inmates were unaccounted for and the jail was almost completely destroyed.
Pensacola was soaked by record-setting rains this week. Parts of the jail had flooded and it was running on generator power at the time of the blast. Barnes said the toilets weren't working, so inmates had to use plastic trash bags.
Authorities blocked off roads leading to the detention center and relatives and attorneys for the inmates stood behind police tape, trying to figure out where loved ones had been taken and who was injured and killed. Many family members were angry because they said they were left in the dark.
About 600 inmates - 200 men and 400 women - were in the building at the time of the explosion. Barnes said during the evacuation, hundreds of inmates and corrections officers had to use one stairwell, "everyone pushing and bleeding."
The names of the two inmates killed weren't immediately released.
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