The mishap took place around 1 am when the car was going to Dharchula from Tawaghat, SDM (Dharchula) Rajkumar Pandey said.
Three of those killed were residents of Nepal's Darchula district and two were from Dharchula sub-division's Jumna village in Uttarakhand, he said.
Om Prakash (45), his wife Hira Devi (42) and their 12- year-old daughter Priyanka from Nepal were killed in the accident, Pandey said.
The injured have been admitted to the Dharchula hospital, the official said.
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