Regional fire brigade chief Chryssanthos Athanassopoulos said "over 35 vehicles" were involved in the crash.
Repair work had shut down Egnatia's eastbound lanes and vehicles were being diverted 75 kilometres west of Thessaloniki, Greece's second-largest city.
A truck coming up to the diversion point did not slow down today and struck a car, which caught fire and caromed into the cars in front.
Firefighters said the dead include two women, a man and a charred body pulled from the burning car.
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