The incident occurred in Mastung district's Splingi area where three security personnel and a passerby were injured.
An improvised explosive device (IED) was used for the roadside explosion which targeted a vehicle of security forces, Geo News reported.
The area was cordoned off following the attack, it said.
On Friday, Pakistan's Senate deputy chairman escaped an assassination bid with injuries when the Islamic State suicide bomber targeted his convoy, killing 25 people and wounding 45 others in the restive Balochistan province.
The area where the explosion took place is approximately 70 kilometres from provincial capital Quetta.
The Islamic State took responsibility for the attack.
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