It called on the international community and Turkey to act urgently to ensure Syrians who have fled the four-and-a-half year conflict have greater access to education.
"Failing to provide Syrian children with education puts an entire generation at risk," said Stephanie Gee of HRW's refugee rights programme.
"With no real hope for a better future, desperate Syrian refugees may end up putting their lives on the line to return to Syria or take dangerous journeys to Europe."
Financial hardship was a major obstacle preventing Syrian children going to class in Turkey, HRW said, with refugees not permitted to work legally and often unable to afford any school fees or transport charges.
"Parents are often unable to provide for their families on the minimal income they make in the informal labour market, and as a result child labour is rampant among the Syrian refugee population."
Many were also unable to attend school because of the language barrier, while others faced bullying and social integration difficulties and in some cases they were even turned away, HRW said.
More than four million Syrians have fled the conflict since March 2011, with the number of dead estimated at more than 250,000.
Turkey, which is hosting more than 2.2 million refugees alone, last year agreed to grant Syrian children access to public schools and to authorise temporary education centres set up by charities or other organisations.
But out of a total of 708,000 school-age children from Syria, only 212,000 were enrolled in formal primary or secondary education last year, HRW said, quoting Turkish education ministry figures.
