Xinjiang has seen a wave of unrest, labelled by authorities as "terrorism" and blamed on "separatists", which has sometimes spread to other parts of China.
Information in the area is strictly controlled by authorities, and the Washington-based Uyghur Human Rights Project (UHRP) used data from Chinese and overseas media reports for its analysis, giving ranges for most of its figures.
Between 457 and 478 people died last year, it said, adding it had been able to identify 235-240 as Uighur and 80-86 as Han, China's ethnic majority.
The rising toll highlights the "excessive force" used by China and a "deterioration in the security environment" since Xi Jinping became Chinese president two years ago, the report said.
The findings were "alarming in a number of aspects", UHRP director Alim Seytoff said.
"It tells us that China's crackdown on Uighurs is only exacerbating the violence....And killing more Uighurs," he said.
The report did not include incidents outside Xinjiang, such as a mass stabbing at a railway station in Kunming last March, when 31 people were killed and four attackers died.
"In a troubling number of incidents police killed all alleged 'perpetrators'," the UHRP said in a statement late yesterday.
"The possibility exists that excessive force and extrajudicial killings are a feature of the Chinese state's security approach to incidents," it added.
Xinjiang witnessed its bloodiest incident since 2009 when 37 civilians and 59 "terrorists" were killed in an attack on a police station and government offices in July in Shache district, known as Yarkand in the Uighur language.
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