The blast happened at about 7:30 pm (1830 GMT) yesterday at the Nagarshiku filling station in the Hotoro area of Kano, causing a fire that engulfed the facility and set cars ablaze.
The petrol station is opposite the scene of a July 28 suicide attack by a female bomber and is used as a base by a military unit that patrols the area, indicating troops may have been the target.
The soldiers park their patrol vans inside the Nagarshiku petrol station at night, from where they coordinate their operations, local residents said.
"The vehicle exploded causing six deaths, including three policemen. Five were injured. It is obviously a suicide attack.
"It is too early to say who was responsible but it all bears the hallmark of the terrorists we've been battling," he added, referring to Boko Haram Islamists who have repeatedly attacked Kano.
The July 28 blast saw a woman detonate low-calibre explosives also at a petrol station, targeting women who had lined up to buy kerosene, police said at the time.
The double bombings were among five to hit Kano in a week, forcing the authorities to cancel celebrations for the end of the Muslim holy month of Ramadan.
Before then, Kano had seen a decline in Boko Haram attacks.
Yesterday's blast destroyed two military vehicles and left a wide crater in the ground, according to an AFP reporter at the scene.
The fire service were able to douse the flames before it reached a fuel truck, which witnesses had earlier claimed was rammed by the car and exploded as it was delivering its cargo.
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