The incident took place in Khuzdar district of the province. The Karachi-bound bus rammed into the tanker which was coming from the opposite direction, Dawn reported.
The injured people include women and children who were rushed to nearby hospitals where an emergency was declared. The dead bodies were shifted to the hospital.
According to the prima facie investigations, the driver of the bus lost control due to over speeding which resulted in the vehicle getting collided with the tanker coming from the opposite direction, officials said.