Alexander will voice the character Bourbon Verlander, a graduate from Yale University who started a scheme of for-profit colleges, Entertainment Weekly reported.
"Simpsons" longtime character Mr Burns will create Burns University, a jab at Trump's Trump University.
"He has a very evil scheme that is a little reminiscent of the film 'Ex Machina,' where he has an army of androids built to capture all the student loans that the government is giving out," executive producer Al Jean said.
The episode will air in early 2017 during the 28th season of the animated Fox series.
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