The Britain-based Syrian Observatory for Human Rights said five children were among the dead today in the rebel-held district of Marjeh in east Aleppo.
Dozens more people were wounded or still trapped under rubble.
Of the 45 civilians killed, the highest number of dead were in Qaterji, where Russian raids claimed 17 lives overnight, said Observatory head Rami Abdel Rahman.
An AFP correspondent in the eastern districts said White Helmets rescuers were still working Monday morning to pull about 20 people out of the rubble in Qaterji.
Both Russian and Syrian warplanes are carrying out air strikes over Aleppo in support of a major offensive by regime forces to capture rebel-held parts of the northern city.
The Observatory -- which relies on a network of sources inside Syria for its information -- says it determines what planes carried out raids according to their type, location, flight patterns and the munitions involved.
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