The report said it had gathered evidence of "a deeply flawed US military justice system that cements a culture of impunity" in dealing with Afghan civilian deaths and injuries caused in NATO coalition operations since 2001.
President Hamid Karzai has often castigated US forces for civilian casualties, but NATO's International Security Assistance Force (ISAF) says it takes all allegations of civilian casualties seriously and investigates each alleged incident.
"After any incident in which civilians have been killed by US forces, (the US must) ensure... Wherever there is sufficient admissible evidence, suspects are prosecuted," said the report entitled "Left in the Dark".
It detailed a US bombing in 2012 when women were collecting firewood in the mountains of Laghman province.
Seven women and girls were killed and seven more were injured.
Ghulam Noor, who lost his 16-year-old daughter Bibi Halimi in the attack, brought the female bodies to the district centre after hearing NATO forces claimed that only insurgents had been killed.
"I have no power to ask the international forces why they did this. I can't bring them to court."
Amnesty said villagers filed complaints with the provincial governor, but international forces in Afghanistan are immune from Afghan legal processes and no one ever contacted family members to investigate the attack.
The ISAF press office in Kabul referred enquiries over the report to the US Department of Defence.
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