The two were last photographed together in January and had been appearing less frequently on each other's social media, reported E! online.
"Amy and Ben have ended their relationship after thoughtful consideration and remain friends," Schumer's representative confirmed.
Schumer, 35, last posted a photo with Hanisch, 30, on March 12 ahead of the Golden Globes, which they attended together. The Chicago-based furniture designer did not accompany the star at the premiere of her latest film "Snatched" earlier this month.
In an interview with Howard Stern on May 3, Schumer had said that she and Hanisch were still dating.
The comedienne and Hanisch met on a dating app around November 2015. They went public with their then-budding relationship in January 2016.
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