National Radio of Angola said that Defence Minister Joao Lourenco would take over as MPLA leader, in news confirmed to AFP by Joao Pinto, a senior member of the party.
"The president will not be a candidate and he already has a successor," Pinto told AFP.
"It will be Joao Lourenco, who will be presented to members of the party on December 10 when we celebrate the party's anniversary."
At a meeting of the MPLA (People's Movement for the Liberation of Angola) today in Luanda, Dos Santos, 74, launched his party's campaign for the election, but declined to say if he would seek a new term.
He made a surprise announcement in March that he would step down in 2018, but has given no further details about any resignation plan.
Angola does not directly elect a president, but rather the leader of the winning party becomes head of state.
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