Patten, a former Conservative politician and the last British governor of Hong Kong before the handover to China in 1997, said he had been admitted to hospital in late April after suffering serious chest pains.
The BBC, the world's largest public broadcaster, said that the 69-year-old Patten would be "standing down with immediate effect on health grounds following major heart surgery".
He took the post as chairman of the BBC Trust in April 2012.
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