Affleck, 44, is going to take some time to focus on his wellness and his family, reported Variety.
The film will move forward without him; it is casting up quickly. Affleck is expected to be at San Diego Comic-Con this week to promote "Justice League".
The action thriller has faced obstacles dating all the way back to when Kathryn Bigelow was on board to direct from a script by Mark Boal. Bigelow left the movie years ago with JC Chandor coming on to replace her.
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