Bhupathi and Uzbekistan's Istomin defeated the Austrian-Romanian pair 4-6, 6-3, 16-14 in an hour and 29 minutes to make the last-eight stage.
Saving five break points was key to Bhupathi and Istomin's win even as they committed seven double faults.
The Indo-Uzbek pair cashed in on both the break chances that came their way.
They will now clash with second seeded Indo-Pak team of Rohan Bopanna and Aisam-ul-haq Qureshi.
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