Blood test to detect psychosis risk

A blood test may help identify if someone is at the risk of developing serious brain disorders such as schizophrenia.
A study led by University of North Carolina at Chapel Hill researchers represents an important step forward in the accurate diagnosis of people who are experiencing the earliest stages of psychosis.
Psychosis includes hallucinations or delusions that define the development of severe mental disorders such as schizophrenia.
Schizophrenia emerges in late adolescence and early adulthood and affects about 1 in every 100 people. In severe cases, the impact on a young person can be a life compromised, and the burden on family members can be almost as severe.

The study shows that a blood test, when used in psychiatric patients experiencing symptoms that are considered to be indicators of a high risk for psychosis, identifies those who later went on to develop psychosis.
"The blood test included a selection of 15 measures of immune and hormonal system imbalances as well as evidence of oxidative stress," said Diana O Perkins, professor of psychiatry in the UNC School of Medicine and corresponding author of the study.

"While further research is required before this blood test could be clinically available, these results provide evidence regarding the fundamental nature of schizophrenia, and point towards novel pathways that could be targets for preventative interventions," Perkins said.

"Modern, computer-based methods can readily discover seemingly clear patterns from nonsensical data," said Clark D Jeffries, bioinformatics scientist at the UNC-based Renaissance Computing Institute (RENCI).
"Added to that, scientific results from studies of complex disorders like schizophrenia can be confounded by many hidden dependencies. Thus, stringent testing is necessary to build a useful classifier. We did that," said Jeffries.
The study was published in the journal Schizophrenia Bulletin.