The device, which was placed between two cars near the checkpoint at Al-Galaa Square in Dokki neighbourhood, exploded at about 7:15 am local time, a security official said.
Previously, security officials said that assailants threw a homemade bomb at the checkpoint.
Egypt has been rocked by a series of bombings and shootings carried out by militants since the military ousted Islamist president Mohamed Morsi in July.
The military-installed authorities say militants have killed about 500 people since the overthrow of Morsi.
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