Brain nicotine signals link smoking and schizophrenia

Schizophrenia is associated with increased rates and intensity of tobacco smoking, scientists say.
A growing body of research suggests that the relationship between schizophrenia and smoking stems, in part, from an effort by patients to use nicotine to self-medicate symptoms and cognitive impairment associated with the disease.
The authors found that the level of nicotine receptors in the brain was lower in schizophrenia patients than in a matched healthy group.
Further, smoking, which is known to increase the levels of receptors for nicotine in the brain, had this effect in both groups, although was blunted in schizophrenia.
However, in the schizophrenia group, the smoking-related increase in the level of nicotine receptors was associated with lower levels of social withdrawal, blunted emotional and motivational responses, as well as better cognitive function.

Nicotine mimics the actions of a natural chemical messenger, acetylcholine, which stimulates the receptors for nicotine in the brain.

To conduct the study, Yale University School of Medicine researchers used single photon emission computed tomography to quantify the availability of nicotinic acetylcholine receptors in smoking and nonsmoking individuals with schizophrenia and healthy subjects.
"We found a blunted effect of tobacco smoking on the nicotinic acetylcholine receptors system in individuals with schizophrenia," said first author and assistant Professor Dr Irina Esterlis.
"Furthermore, we found that lower receptor availability of nicotinic acetylcholine receptors in smokers with schizophrenia is associated with worse negative symptoms and worse performance on tests of executive function," Esterlis said.

These findings may be relevant to the high rates of smoking in schizophrenia, researchers said.
"The data seem to suggest that smoking might produce some clinical benefits for some patients by increasing the availability of receptor targets for nicotine in the brain," said Dr John Krystal, Editor of Biological Psychiatry, the journal in which the study is published.
"This finding adds to evidence that brain nicotine-related signalling might play a role for new medications developed to treat schizophrenia," he said.
"These findings suggest that nicotinic acetylcholine receptors may be a target for developing treatments for negative symptoms and cognitive deficits associated with schizophrenia, for which no effective treatments exist," added Esterlis.