Some of the changes are predicted to help game players respond to new information. Other changes are associated with distractibility and poor impulse control, researchers said.
"Most of the differences we see could be considered beneficial. However the good changes could be inseparable from problems that come with them," said senior author Jeffrey Anderson, associate professor at the University of Utah in US.
Those with internet gaming disorder are obsessed with video games, often to the extent that they give up eating and sleeping to play.
The job of the salience network is to focus attention on important events, poising that person to take action. In a video game, the enhanced coordination could help a gamer to react more quickly to the rush of an oncoming fighter.
"Hyperconnectivity between these brain networks could lead to a more robust ability to direct attention towards targets, and to recognise novel information in the environment," said Anderson.
"The changes could essentially help someone to think more efficiently," he said.
Hyperconnectivity between the two regions is also observed in people with poor impulse control.
It is not known whether persistent video gaming causes rewiring of the brain, or whether people who are wired differently are drawn to video games, the researchers said.
According to Doug Hyun Han, professor at Chung-Ang University in South Korea, this research is the largest, most comprehensive investigation to date of brain differences in compulsive video game players.
The brain scans were compared to those from 80 boys without the disorder, and analysed for regions that were activated simultaneously while participants were at rest, a measure of functional connectivity.
The study was published in the journal Addiction Biology.
