Wilful neglect of patients is set to be made a criminal offence under reforms being introduced in the wake of the scandal at Stafford Hospital in central England, where up to 1,200 people died as a result of poor care between 2005 and 2009.
A three-year public inquiry into the scandal heard horrifying examples of abuse and neglect, including patients left starving and soiled in their beds, or so thirsty that they drank water from vases.
The new offence will be modelled on the wilful neglect of adults under Britain's Mental Capacity Act, which is punishable by up to five years in prison.
The health ministry is set to hold a public consultation on appropriate sentencing for the new offence.
Cameron said Britain was "full of brilliant doctors, nurses and other health workers who dedicate their lives to caring for our loved ones".
He added: "Never again will we allow substandard care, cruelty or neglect to go unnoticed and unpunished."
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