Spears, 31, will complete a two-year residency at the Planet Hollywood with an expected 50 shows each year, reported the Huffington Post.
"I'm going to definitely do the greatest hits but I'm going to have to put some of my new material in it to just keep it fresh," she said on a TV show.
The news of the show, which will be called 'Piece of Me', comes after the release of the singer's latest single.
Tickets for Spears' show are available for purchase from September 17.
