The Blues, chasing their first English league crown since 2010, re-established their stranglehold on the title race thanks to Loic Remy's late winner at the KC Stadium on Sunday.
And with Chelsea holding a game in hand on second placed Manchester City, Mourinho says they are now firm favourites to lift the trophy.
"The title race should be over," Mourinho said. "The title race in normal conditions, Chelsea should have eight, 10, 12 points more than we have - title race over.
"The maximum lead we had was eight but when we had eight we had more matches to go.
"In this moment we have a six-point lead, one match in hand, that can help us have a bigger distance with eight matches to go to our opponents.
"They (City) can make 24 points, if they can make 24 points for us it is a question of mathematics to see how much we need. I'm pretty confident. I believe in my players, I believe that we can do it."
- Conservative and collective -
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Goals from Eden Hazard and Diego Costa put Mourinho's team two goals ahead in the first nine minutes, but struggling Hull showed admirable determination to draw level with two goals in quick succession from Ahmed Elmohamady and Abel Hernandez before half-time.
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