The state-owned Tsinghua Unigroup will open the facility in the city of Nanjing in eastern Jiangsu province, where it will mainly produce chips used in consumer electronics such as cellphones, cameras and computers, according to a statement posted Thursday on the company's official website.
The project "is of great significance to the independent innovation, large-scale production, and marketization of China's integrated circuit industry", the statement said.
The announcement comes after attempts by the company to take-over US chip makers Micron Technology and Sandisk were curbed by the Committee on Foreign Investment in the United States (CFIUS) over national security concerns.
China was the largest market for semiconductors in the world in 2015. Its excessive dependence on imported chips has raised concern in Beijing over the country's national security, according to a report by the US Department of Commerce.
In 2014, Chinese authorities pledged 100 billion yuan (USD 14.6 billion) to support the industry, with the aim of building a "globally competitive semiconductor sector by 2030", according to two statements by China's Ministry of Industry and Information Technology in 2014 and 2015.
The drive by China to expand its role in the market, long dominated by US firms like Intel and Qualcomm, has raised concerns in Washington.
A report to President Barack Obama by a presidential science panel last month warned that China is set to challenge American dominance in the industry.
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