Architects of the sprawling deal, which would avert a government shutdown, still must rally the necessary support from skeptical rank-and-file lawmakers, but the legislation has the backing from Republican congressional leaders and the Senate's top Democrat Harry Reid.
The fiscal year 2016 spending bill, known as an "omnibus," has become a year-end catch-all that includes priorities from both parties, and leaves out some pet projects that may make it difficult for some lawmakers to sign on.
"I have no reason to believe we're going to have a shutdown," Ryan told reporters.
"In divided government, you don't get everything you want. This is the result of a bipartisan, bicameral compromise," he added.
"I think everybody can point to something that gives them a reason to be in favor of both of these bills."
The omnibus lifts the 40-year-old ban on US crude oil exports, for years a Republican priority, while extending solar and wind energy tax credits that Democrats say will create renewable energy jobs and reduce carbon emissions.
The omnibus retained the decades-long ban on federal funding for gun research, a major point of contention for Democrats. It also failed to provide assistance for debt-crippled Puerto Rico, which left top House Democrat Nancy Pelosi fuming.
And it includes a two-year moratorium on the so-called medical device tax, a provision of President Barack Obama's health care law that angered Republicans and Democrats alike.
"This is a good compromise," Reid concluded.
And while the White House has expressed opposition to lifting the crude oil export ban and other elements in the omnibus, it said today it was supportive of the overall result.
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