The blaze, known as the Erskine Fire, is raging in an agricultural and oil region of south-central California.
The blaze has spread to nearly 37,000 acres, the California Department of Forestry and Fire Protection (CAL Fire) said.
Some 1,700 personnel have been assigned to battle the wildfire, which is just 10 per cent contained, CAL Fire said on Twitter.
At least 75 other homes have fire damage, officials said.
Unusually high temperatures, bone-dry conditions that make brush and grass flammable, and powerful winds gusting up to 80 to 100 kilometers per hour helped spread the flames of a fire that broke out Thursday afternoon in the sparsely populated Lake Isabella area of Kern County.
"We've located what we believe are human remains," sheriff's spokesman Ray Pruitt told reporters on Saturday. "We are treating it like a crime scene."
Pruitt said the remains were "pretty badly burned."
The cause of the fire is still unknown, but if investigators determine that it was intentionally set then the fire deaths will be treated as homicides, Pruitt said.
Firefighters are having an especially hard time battling the blaze due to rough hills in the area.
"We're looking at increased winds ... High temperatures, low humidity in the single digits -- that makes this a very difficult firefight," Mohler said.
The National Weather Service forecast low humidity and a temperature of 37.2 degrees Celsius today, unusually hot for this time of the year in that region of California.
Thousands of area residents affected by the fire have been evacuated to shelters run by groups like the American Red Cross.
"I've lost everything -- all I have is what I've got on," local resident Fred Coleman told CBS 5KPIX television, interviewed at an evacuation center in the town of Kernville.
Authorities have closed several highways and evacuated two schools and a retirement home in the affected area.
California is experiencing a record five-year drought and trees and brush are at risk of igniting from the smallest spark.
More than 14 large fires are currently raging in the United States, mostly in the southwest, where a record heat wave left at least five dead last Sunday.
