The quake that hit minutes before midnight Thursday was strong enough to cause buildings to sway violently in the capital city more than 650 miles (1,000 kilometers) away. As beds banged against walls, people still wearing pajamas ran out of their homes and gathered in frightened groups.
Rodrigo Soberanes, who lives near San Cristobal de las Casas in Chiapas, the state nearest the epicenter, said his house "moved like chewing gum."
The head of Mexico's civil defense agency confirmed the deaths of 45 people in the southern state of Oaxaca. Another 12 people died in Chiapas and three more in the Gulf coast state of Tabasco.
The worst-hit city appeared to be Juchitan, on the narrow waist of Oaxaca known as the Isthmus. About half of the city hall collapsed in a pile of rubble, and streets were littered with the debris of ruined houses.
Families were jerked awake by the grating howl of the capital's seismic alarm. Some shouted as they dashed out of rocking apartment buildings. Even the iconic Angel of Independence Monument swayed as the quake's waves rolled through the city's soft soil.
Elsewhere, the extent of destruction was still emerging. Hundreds of buildings collapsed or were damaged, power was cut at least briefly to more than 1.8 million people and authorities closed schools Friday in at least 11 states to check them for safety.
The epicenter was in a seismic hotspot in the Pacific where one tectonic plate dives under another. These subduction zones are responsible for producing some of the biggest quakes in history, including the 2011 Fukushima disaster and the 2004 Sumatra quake that spawned a deadly tsunami.
The quake struck at 11:49 (local time) Thursday. Its epicenter was 102 miles (165 kilometers) west of Tapachula in Chiapas, with a depth of 43.3 miles (69.7 kilometers), the USGS said.
Three people were killed in San Cristobal, including two women who died when a house and a wall collapsed, Chiapas Gov. Manuel Velasco said.
"There is damage to hospitals that have lost energy," he said. "Homes, schools and hospitals have been damaged."
In Tabasco, one child died when a wall collapsed, and an infant died in a children's hospital when the facility lost electricity, cutting off the ventilator, Gov. Arturo Nunez said.
The quake triggered tsunami warnings and some tall waves, but there was no major damage from the sea. Authorities briefly evacuated a few residents of coastal Tonala and Puerto Madero because of the warning.
In neighbouring Guatemala, President Jimmy Morales appeared on national television to call for calm while emergency crews surveyed damage. Officials later said only four people had been injured and several dozen homes damaged. The quake occurred near the point of collision between three tectonic plates, the Cocos, the Caribbean and the North American.
The area has seen at least six other quakes of magnitude 7.0 or greater since 1900. Three of those occurred within a nerve-wracking nine-month span in 1902-1903, according to Mexico's National Seismological Service.
"It's unusual, but it's not unheard of," said seismologist Susan Hough of the USGS, describing how stresses on the seafloor can produce big earthquakes.
The new quake matched the force of a magnitude 8.1 quake that hit the country on June 3, 1932, roughly 300 miles (500 kilometers) west of Mexico City.
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