Nobel-winner JM Coetzee failed to make the six-name list for the world's leading English-language fiction award, which featured only one previous nominee, South African-born British author Deborah Levy.
Her "Hot Milk" is a story of an intense relationship between a sickly mother and her daughter set in a small Spanish fishing village which the jury said in a statement examines "female rage and sexuality".
Scottish writer Graeme Macrae Burnet's "His Bloody Project" thriller "paints a painfully realistic picture of poverty in the tiny crofting community of Culduie in the Scottish Highlands," the jury said.
The three other books shortlisted are David Szalay's "All That Man Is", a portrait of masculinity, Madeleine Thien's "Do Not Say We Have Nothing" about classical music in revolutionary China and Paul Beatty's "The Sellout", a satire on US urban life.
"The final six reflect the centrality of the novel in modern culture -- in its ability to champion the unconventional, to explore the unfamiliar, and to tackle difficult subjects," jury chair Amanda Foreman, a historian, said in a statement.
The Foyles bookshop chain said in a statement that the shortlist was "excitingly wide-open, with Deborah Levy the only well-known author left".
The winner will be announced in London on October 25.
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