The 41-year-old actress opened up about his divorce from Will Kopelman on the premier of Chelsea Handler's talk show.
"It's a tough time. It's a hard thing to go through. It's like your being put on a cheese grater and every second, going, 'Ah! This wasn't the plan!," Barrymore said.
The "Blended" star said there is a big difference between breaking up with someone you've been dating and ending your marriage.
"When you break up with somebody, you're like, 'Yeah, that didn't work,' (but) when you get divorced you're like, 'I'm the biggest failure. This is the biggest failure'. It's so shameful and hard to actually go through that, even privately."
"There has been this really nice feeling of something very fluid and positive and the opposite of how I felt inside. Everyone has just been so cool and chill and nice about everything that it quelled by own fears and demons about how we sort of have to go through things in life," she said.
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