The Muslim-majority border region has seethed with violence for over a decade as ethnic Malay insurgents battle the Buddhist-majority state for more autonomy.
The latest attack struck the town of Pattani around 2pm, with two bombs going off in quick succession outside a supermarket near the city centre.
"The first bomb was small and no one was hurt but the second bomb was huge -- I don't know yet whether it's a car bomb or not," Captain Preecha Prachumchai of Pattani provincial police told AFP.
Pictures posted by rescue workers on Twitter showed a thick plume of black smoke over the supermarket car park and some damage to the store entrance.
Near-daily shootings and bomb attacks have claimed more than 6,800 lives since 2004, with both sides accused of rights abuses and atrocities.
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