However, the NSE Nifty managed to eke out a small gain and closed above the crucial 7,500-mark.
Though the first half was upbeat, tracking global peers on Fed's dovish stance, things changed dramatically later as profit-booking emerged, capping broader advances.
"Federal Open Market Committee has signaled that future rate hikes will be on the low gear, indicating only two rate hikes in CY16 due to tepid global growth. This is positive for emerging markets to attract foreign funds," said Vinod Nair, Head-Fundamental Research at Geojit BNP Paribas.
"Now the ball is in RBI's court, since the domestic data like inflation and fiscal deficit are at a comfort level," Nair added.
Sensex started-off on a strong foot and advanced further to hit a high of 24,948.30 points, however, on selling in bluechips like healthcare, it slipped into the negative zone to a low of 24,576.52, before settling 5.11 points or 0.02 per cent lower at 24,677.37.
Shares of pharma companies led by Lupin, Cipla, Dr Reddy's and Sun Pharma came under selling pressure towards the fag-end of session, falling by up to 4.23 per cent.
On the other hand, state-owned oil marketing companies hogged the limelight by surging 6 per cent after Indian Oil Corporation announced an increase in petro and diesel prices.
BPCL went up by 5.67 per cent to 862.65, HPCL gained 3.28 per cent to Rs 758.35 and IOC climbed 2.64 per cent to Rs 398.75.
Globally, other Asian markets depicted a mixed trend with Hong Kong's Hang Seng ending 1.21 per cent higher while Nikkei fell 0.22 per cent. Shanghai ended 1.20 per cent higher.
Back home, of the 30-share Sensex pack, 17 scrips ended
higher while 13 finished lower.
Major gainers were BHEL (4.23 pc), GAIL (4.04 pc), Adani Ports (3.09 pc), ONGC (2.95 pc), L&T (0.93 pc), Bajaj Auto (0.90 pc), Axis Bank (0.87 pc), TCS (0.81 pc), Hero MotoCorp (0.77 pc) and Infosys (0.71 pc).
However, Lupin dropped by 4.23 per cent followed by Cipla 1.54 per cent, HDFC 1.44 per cent, HDFC Bank 1.25 per cent, M&M 1.15 per cent, Tata Steel 1.14 per cent, Dr Reddy's 1.07 per cent and Sun Pharma 1.01 per cent.
The market breadth remained negative as 1,309 shares ended lower, 1,303 closed higher while 183 ruled steady.
The total turnover rose to Rs 2,627.87 crore from Rs 2,249.88 crore yesterday.
