Ambulances, helicopters and other rescue vehicles raced to the scene in Iran's northern Golestan province as authorities worked to determine the scale of the emergency.
The IRNA news agency quoted Golestan provincial emergency management department head Sadeq Ali Moghadam as saying that 40 to 50 people are believed to be trapped in the mine outside of the town of Azadshahr.
Press TV, the English-language arm of Iranian state television, said two workers had died.
Provincial spokesman Ali Yazerloo said the blast happened at 12:45 PM local time and that the provincial governor is heading to the scene.
At least 25 people who had entered the mine to try to save those trapped had to be taken to the hospital after inhaling the gas, said Hamidreza Montazeri, the deputy head of the emergency management department in Golestan.
Iranian news reports said the explosion happened while workers were changing shifts.
Semi-official Iranian news agencies posted pictures online from the scene, showing ambulances and emergency workers gathered at the mouth of the mine. Some images showed dazed workers, covered in coal dust, being helped by bystanders or laying on the ground as rescuers rushed past with oxygen bottles.
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