The general prosecutor's office said in a statement that it issued arrest warrants for the general guide of the Muslim Brotherhood, Mohammed Badie, as well as for his deputy Mahmoud Ezzat.
Eight other top Brotherhood leaders wanted by the prosecution, included Mohammed al-Beltagui, Mahmud Ezzat and Safwat Hegazi, the sources said.
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Several leading Brotherhood figures are already in detention and warrants have been issued for hundreds more.
Meanwhile, a foreign ministry spokesman told reporters today that Egypt's ousted president Morsi is in a "safe place" following his overthrow by the army.
He added that no charges had been levelled against Morsi yet.
"Morsi is in a safe place, for his safety and he is being treated with dignity," Badr Abdelatty told reporters, in the first public statement on the whereabouts of the 61-year-old leader who was ousted by the army last week.
"He is not charged with anything up till now," he said.
Egypt's military-backed interim government was faced with tough hurdles as both opponents and supporters of ousted president Morsi slammed a temporary charter that seeks to steer the divided nation through a rocky transition phase.
Uncertainty ruled in Egypt today as the Muslim holy month of Ramadan began and the military said it would address the issues of this week's deadly violence.
Clashes on Monday between Morsi's supporters and security forces killed 51 people and wounded another 435. It was the deadliest day in Cairo since the revolution that forced former President Hosni Mubarak from office in 2011.
Nearly 650 people, mostly backers of Morsi, were also detained as they tried to storm the Republican Guard headquarters here, where the ousted leader is reportedly under house arrest.
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