"I welcome the decision of the Scottish people to maintain the unity of the United Kingdom," European Commission head Jose Manuel Barroso said.
"This outcome is good for the united, open and stronger Europe that the European Commission stands for," Barroso said in a statement.
EU president Herman Van Rompuy said the outcome meant Britain "is and will remain an important member of the European Union to the benefit of all citizens and member states."
Neither Van Rompuy nor Barroso referred to the "In-Out" referendum on EU membership promised by British premier David Cameron for 2017 but Brussels is watching developments on that count carefully, stressing repeatedly how important the country is to the overall success of the bloc.
He said the commission welcomed the fact that during the independence debate "the Scottish Government and the Scottish people have repeatedly reaffirmed their European commitment."
"The European Commission will continue to engage in a constructive dialogue with the Scottish Government, in areas under its responsibility, that are important to Scotland's future, including jobs and growth, energy, climate change and the environment, and smarter regulation."
