The meeting between Zarif and the three European parties to the landmark 2015 agreement comes after Iran warned the world today to prepare for the withdrawal of the United States.
Thursday's meeting comes against a backdrop of high political tension in Iran following recent protests which claimed 21 lives, though Zarif has dismissed the idea the unrest would be on the agenda.
Iran signed the accord with six world powers, agreeing to curb its nuclear programme in exchange for the lifting of many international sanctions, but US President Donald Trump has condemned the deal and threatened to pull out.
"The meeting will take place in the context of the ongoing work to ensure a full and continued implementation of the Joint Comprehensive Plan of Action," the statement added, using the official name for the deal.
The EU, which played an important role in brokering the Iran nuclear deal, has been lobbying US lawmakers not to pull out and so far Trump has continued to waive nuclear-related sanctions at regular intervals as required under the agreement.
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