He is the second big casualty for Pune Supergiants after former England batsman Kevin Pietersen was ruled out due to calf muscle injury.
South African right hander Du Plessis took to twitter to confirm the development.
"And so my Ipl tournament unfortunately comes to and end.Broken finger and out for 6 weeks.Thanx India and @RPSupergiants it's been fun," he tweeted.
If Du Plessis is out of action for six weeks, he might also miss South Africa's tri-nation ODI series with West Indies and Australia.
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